Selected Publications
Weitzer S, Lehane C and Uhlmann F. A model for ATP hydrolysis-dependent binding of cohesin to DNA. Curr Biol 2003; 13: 1930-1940. PubMed
Sullivan M, Higuchi T, Katis VL and Uhlmann F. Cdc14 phosphatase induces rDNA condensation and resolves cohesin-independent cohesion during budding yeast anaphase. Cell 2004; 117: 471-482. PubMed
Hornig NCD and Uhlmann F. Preferential cleavage of chromatin-bound cohesin after targeted phosphorylation by Polo-like kinase. EMBO J 2004; doi:10.1038/sj.emboj.7600303. PubMed PDF (UKPMC)
Lengronne A, Katou Y, Mori S, Yokobayashi S, Kelly GP, Itoh T, Watanabe Y, Shirahige K and Uhlmann F. Cohesin relocation from sites of chromosomal loading to places of convergent transcription. Nature 2004; 430: 573-578. PubMed
Higuchi T and Uhlmann F Stabilization of microtubule dynamics at anaphase onset promotes chromosome segregation. Nature 2005; 433: 171-176. PubMed
Primary Research Publications
2009
Kapuy O, He E, Lopez-Aviles S, Uhlmann F, Tyson JJ, Novak B. System-level feedbacks control cell cycle progression. FEBS Lett 2009; 583 (24 Spec Iss):3992-3998. DOI: 10.1016/j.febslet.2009.08.023.
Kapuy O, He E, Uhlmann F, Novak B. Mitotic exit in mammalian cells. Mol Syst Biol 2009; 5 :324. PubMed; DOI: 10.1038/msb.2009.86.
Uhlmann F. A matter of choice: the establishment of sister chromatid cohesion. EMBO Rep 2009; 10 (10):1095-1102. PubMed.
Selth LA, Lorch Y, Ocampo-Hafalla MT, Mitter R, Shales M, Krogan NJ, Kornberg RD, Svejstrup JQ. An Rtt109-Independent Role for Vps75 in Transcription-Associated Nucleosome Dynamics. Mol Cell Biol 2009; 29 (15):4220-4234. PubMed.
Schmidt CK, Brookes N, Uhlmann F. Conserved features of cohesin binding along fission yeast chromosomes. Genome Biol 2009; 10 (5):R52. UKPubMed (open access); PubMed; DOI: 10.1186/gb-2009-10-5-r52.
Lopez-Aviles S, Kapuy O, Novak B, Uhlmann F. Irreversibility of mitotic exit is the consequence of systems-level feedback. Nature 2009; 459 (7246):592-595. UKPubMed (open access); PubMed.
Mendoza M, Norden C, Durrer K, Rauter H, Uhlmann F, Barral Y. A mechanism for chromosome segregation sensing by the NoCut checkpoint. Nat Cell Biol 2009; 11 (4):477-483. PubMed.
Csikasz-Nagy A, Kapuy O, Toth A, Pal C, Jensen LJ, Uhlmann F, Tyson JJ, Novak B. Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation. Mol Syst Biol 2009; 5 :236. PubMed.
2008
Queralt E, Uhlmann F. Cdk-counteracting phosphatases unlock mitotic exit. Curr Opin Cell Biol 2008; 20 (6):661-668. PubMed.
Queralt E, Uhlmann F. Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase. J Cell Biol 2008; 182 (5):873-883. PubMed.
D'Ambrosio C, Schmidt CK, Katou Y, Kelly G, Itoh T, Shirahige K, Uhlmann F. Identification of cis-acting sites for condensin loading onto budding yeast chromosomes. Genes Dev 2008; 22 (16):2215-2227. PubMed.
D'Ambrosio C, Kelly G, Shirahige K, Uhlmann F. Condensin-dependent rDNA decatenation introduces a temporal pattern to chromosome segregation. Curr Biol 2008; 18 (14):1084-1089. PubMed.
Ben-Shahar TR, Heeger S, Lehane C, East P, Flynn H, Skehel M, Uhlmann F. Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 2008; 321 (5888):563-566. PubMed.
Uhlmann F. Molecular biology - Cohesin branches out. Nature 2008; 451 (7180):777-778. PubMed.
Bernard P, Schmidt CK, Vaur S, Dheur S, Drogat J, Genier S, Ekwall K, Uhlmann F, Javerzat JP. Cell-cycle regulation of cohesin stability along fission yeast chromosomes. EMBO J 2008; 27 (1):111-121. PubMed; DOI: 10.1038/sj.emboj.7601955.
2007
Ocampo-Hafalla MT, Katou Y, Shirahige K, Uhlmann F. Displacement and re-accumulation of centromeric cohesin during transient pre-anaphase centromere splitting. Chromosoma 2007; 116 (6):531-544.
Uhlmann F. What is your assay for sister-chromatid cohesion?. EMBO J 2007; 26 (22):4609-4618.
Toth A, Queralt E, Uhlmann F, Novak B. Mitotic exit in two dimensions. J Theor Biol 2007; 248 (3):560-573.
McIntyre J, Muller EGD, Weitzer S, Snydsman BE, Davis TN, Uhlmann F. In vivo analysis of cohesin architecture using FRET in the budding yeast Saccharomyces cerevisiae. EMBO J 2007; 26 (16):3783-3793.
2006
Lengronne A, McIntyre J, Katou Y, Kanoh Y, Hopfner K-P, Shirahige K, Uhlmann F. Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol Cell 2006; 23 (6):787-799.
Queralt E, Lehane C, Novak B, Uhlmann F. Downregulation of PP2A(Cdc-95) phosphatase by separase initiates mitotic exit in budding yeast. Cell 2006; 125 (4):719-732.
Uhlmann F, Hopfner K-P. Chromosome biology: the crux of the ring. Curr Biol 2006; 16 (3):R102-R105.
2005
Queralt E, Uhlmann F. More than a separase. Nat Cell Biol 2005; 7 (10):930-932.
Higuchi T, Uhlmann F. Stabilization of microtubule dynamics at anaphase onset promotes chromosome segregation. Nature 2005; 433 (7022):171-176. UKPubMed (open access).
2004
Hornig NCD, Uhlmann F. Preferential cleavage of chromatin-bound cohesin after targeted phosphorylation by Polo-like kinase. EMBO J 2004; 23 (15):3144-3153.
Lengronne A, Katou Y, Mori S, Yokobayashi S, Kelly GP, Itoh T, Watanabe Y, Shirahige K, Uhlmann F. Cohesin relocation from sites of chromosomal loading to places of convergent transcription. Nature 2004; 430 (6999):573-578. UKPubMed (open access).
Sullivan M, Higuchi T, Katis VL, Uhlmann F. Cdc14 phosphatase induces rDNA condensation and resolves cohesin-independent cohesion during budding yeast anaphase. Cell 2004; 117 (4):471-482.
Uhlmann F. The mechanism of sister chromatid cohesion. Exp Cell Res 2004; 296 (1):80-85.
Sullivan M, Hornig NCD, Porstmann T, Uhlmann F. Studies on substrate recognition by the budding yeast separase. J Biol Chem 2004; 279 (2):1191-1196.
2003
Higuchi T, Uhlmann F. Passenger acrobatics. Nature 2003; 426 (6968):780-781.
Weitzer S, Lehane C, Uhlmann F. A model for ATP hydrolysis-dependent binding of cohesin to DNA. Curr Biol 2003; 13 (22):1930-1940.
Uhlmann F. Separase regulation during mitosis. Biochem Soc Symp 2003; 70 :243-251.
Buonomo SBC, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Toth A, Nasmyth K. Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19. Dev Cell 2003; 4 (5):727-739.
Sullivan M, Uhlmann F. A non-proteolytic function of separase links the onset of anaphase to mitotic exit. Nat Cell Biol 2003; 5 (3):249-254. UKPubMed (open access).
Uhlmann F. Chromosome cohesion and separation: from men and molecules. Curr Biol 2003; 13 (3):R104-R114.
2002
Weitzer S, Uhlmann F. Chromosome segregation: playing polo in prophase. Dev Cell 2002; 2 (4):381-382.
Uhlmann F. Keeping the genome in shape. Nature 2002; 417 (6885):135-136.
Hornig NCD, Knowles PP, McDonald NQ, Uhlmann F. The dual mechanism of separase regulation by securin. Curr Biol 2002; 12 (12):973-982.
Other publications
Kapuy O, He E, López-Avilés S, Uhlmann F, Tyson JJ, Novák B. System-level feedbacks control cell cycle progression. FEBS Lett 2009; 583(24): 3992-3998.
Uhlmann F. A matter of choice: the establishment of sister chromatid cohesion. EMBO Rep 2009; 10(10): 1095-1102.
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