Selected Publications
Smith A, Bracke M, Leitinger B, Porter JC and Hogg N. LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment. J Cell Sci 2003; 116: 3123-3133. PubMed
Henderson R, Lim LHK, Tessier PA, Gavins F, Mathies M, Perretti M and Hogg N. The use of LFA-1 deficient mice to determine the role of LFA-1, Mac-1 and α4 integrin in the inflammatory response of neutrophils. J. Exp. Med. 2001; 194: 219- 226. PubMed
Porter JC, Bracke M, Smith A, Davies D and Hogg N. Signaling through integrin LFA-1 leads to filamentous actin polymerization and remodeling, resulting in enhanced cell adhesion. J Immunol. 2002; 168: 6330-6335. PubMed
McDowall A , Inwald D, Leitinger B, Jones A, Liesner R, Klein N and Hogg N. A novel form of integrin dysfunction involving β1, β2 and β3 integrins. J Clin Invest. 2003; 111: 51-60. PubMed PDF (UKPMC)
Hobbs JAR, May R, Tanousis K, McNeill E, Mathies M, Gebhardt C, Henderson R, Robinson MJ and Hogg N. Myeloid cell function in MRP-14 (S100A9) null mice. Mol Cell Biol. 2003; 23: 2564-2576. PubMed PDF (UKPMC)
Primary Research Publications
2010
Ebisuno Y, Katagiri K, Katakai T, Ueda Y, Nemoto T, Inada H, Nabekura J, Okada T, Kannagi R, Tanaka T, Miyasaka M, Hogg N, Kinashi T. Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners. Blood 2010; 115 (4):804-814. DOI: 10.1182/blood-2009-03-211979.
2009
Croce K, Gao HY, Wang YM, Mooroka T, Sakuma M, Shi C, Sukhova GK, Packard RRS, Hogg N, Libby P, Simon DI. Myeloid-Related Protein-8/14 Is Critical for the Biological Response to Vascular Injury. Circulation 2009; 120 (5):427-436. PubMed.
Herroeder S, Reichardt P, Sassmann A, Zimmermann B, Jaeneke D, Hoeckner J, Hollmann MW, Fischer KD, Vogt S, Grosse R, Hogg N, Gunzer M, Offermanns S, Wettschureck N. Guanine Nucleotide-Binding Proteins of the G(12) Family Shape Immune Functions by Controlling CD4(+) T Cell Adhesiveness and Motility. Immunity 2009; 30 (5):708-720. PubMed.
Svensson L, Howarth K, McDowall A, Patzak I, Evans R, Ussar S, Moser M, Metin A, Fried M, Tomlinson I, Hogg N. Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Nat Med 2009; 15 (3):306-312. UKPubMed (open access); PubMed; DOI: 10.1038/nm.1931.
Evans R, Patzak I, Svensson L, De Filippo K, Jones K, McDowall A, Hogg N. Integrins in immunity. J Cell Sci 2009; 122 (2):215-225. PubMed.
2008
De Filippo K, Henderson RB, Laschinger M, Hogg N. Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways. J Immunol 2008; 180 (6):4308-4315. PubMed.
Downey J, Smith A, Schneider H, Hogg N, Rudd CE. TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice. Immunol Lett 2008; 115 (1):70-72. PubMed; DOI: 10.1016/j.imlet.2007.08.013.
Stanley P, Smith A, McDowall A, Nicol A, Zicha D, Hogg N. Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell. EMBO J 2008; 27 (1):62-75. PubMed; DOI: 10.1038/sj.emboj.7601959.
2007
Miertzschke M, Stanley P, Bunney TD, Rodrigues-Lima F, Hogg N, Katan M. Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration. J Biol Chem 2007; 282 (42):30629-30642.
Segura E, Guerin C, Hogg N, Amigorena S, Thery C. CD8(+) dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo. J Immunol 2007; 179 (3):1489-1496.
Smith A, Stanley P, Jones K, Svensson L, McDowall A, Hogg N. The role of the integrin LFA-1 in T-lymphocyte migration. Immunol Rev 2007; 218 :135-146.
McNeill E, Conway SJ, Roderick HL, Bootman MD, Hogg N. Defective chemoattractant-induced calcium signalling in S100A9 null neutrophils. Cell Calcium 2007; 41 (2):107-121. DOI: 10.1016/j.ceca.2006.05.004.
2006
Schneider H, Downey J, Smith A, Zinselmeyer BH, Rush C, Brewer JM, Wei B, Hogg N, Garside P, Rudd CE. Reversal of the TCR stop signal by CTLA-4. Science 2006; 313 (5795):1972-1975.
Evans BJ, McDowall A, Taylor PC, Hogg N, Haskard DO, Landis RC. Shedding of lymphocyte function-associated antigen-1 (LFA-1) in a human inflammatory response. Blood 2006; 107 (9):3593-3599.
2005
Bertolino P, Schrage A, Bowen DG, Klugewitz K, Ghani S, Eulenburg K, Holz L, Hogg N, McCaughan GW, Hamann A. Early intrahepatic antigen-specific retention of naive CD8(+) T cells is predominantly ICAM-1/LFA-1 dependent in mice. Hepatology 2005; 42 (5):1063-1071.
Semmrich M, Smith A, Feterowski C, Beer S, Engelhardt B, Busch DH, Bartsch B, Laschinger M, Hogg N, Pfeffer K, Holzmann B. Importance of integrin LFA-1 deactivation for the generation of immune responses. J Exp Med 2005; 201 (12):1987-1998.
Smith A, Carrasco YR, Stanley P, Kieffer N, Batista FD, Hogg N. A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes. J Cell Biol 2005; 170 (1):141-151. DOI: 10.1083/jcb.2000412032.
2004
Hogg N, Smith A, McDowall A, Giles K, Stanley P, Laschinger M, Henderson R. How T cells use LFA-1 to attach and migrate. Immunol Lett 2004; 92 (1-2):51-54.
2003
Heasman SJ, Giles KM, Ward C, Rossi AG, Haslett C, Dransfield I. Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation. J Endocrinol 2003; 178 (1):29-36.
Inwald DP, McDowall A, Peters MJ, Callard RE, Klein NJ. CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation. Circ Res 2003; 92 (9):1041-1048.
Holub A, Byrnes J, Anderson S, Dzaidzio L, Hogg N, Huttenlocher A. Ligand density modulates eosinophil signaling and migration. J Leukoc Biol 2003; 73 (5):657-664.
Hogg N, Laschinger M, Giles K, McDowall A. T-cell integrins: more than just sticking points. J Cell Sci 2003; 116 (23):4695-4705.
Smith A, Bracke M, Leitinger B, Porter JC, Hogg N. LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment. J Cell Sci 2003; 116 (15):3123-3133.
Henderson RB, Hobbs JAR, Mathies M, Hogg N. Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood 2003; 102 (1):328-335.
Hogg N. Nicotine has selectively suppressive effects on dendritic cell function. Immunology 2003; 109 (3):329-330.
Wang HY, Moon EY, Azouz A, Wu X, Smith A, Schneider H, Hogg N, Rudd CE. SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates. Nat Immunol 2003; 4 (4):366-374.
Hobbs JAR, May R, Tanousis K, McNeill E, Mathies M, Gebhardt C, Henderson R, Robinson MJ, Hogg N. Myeloid cell function in MRP-14 (S100A9) null mice. Mol Cell Biol 2003; 23 (7):2564-2576.
Ardouin L, Bracke M, Mathiot A, Pagakis SN, Norton T, Hogg N, Tybulewicz VLJ. Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse. Eur J Immunol 2003; 33 (3):790-797.
McDowall A, Inwald D, Leitinger B, Jones A, Liesner R, Klein N, Hogg N. A novel form of integrin dysfunction involving beta 1, beta 2, and beta 3 integrins. J Clin Invest 2003; 111 (1):51-60.
2002
Hogg N, Henderson R, Leitinger B, McDowall A, Porter J, Stanley P. Mechanisms contributing to the activity of integrins on leukocytes. Immunol Rev 2002; 186 :164-171.
Porter JC, Bracke M, Smith A, Davies D, Hogg N. Signaling through integrin LFA-1 leads to filamentous actin polymerization and remodeling, resulting in enhanced T cell adhesion. J Immunol 2002; 168 (12):6330-6335.
Leitinger B, Hogg N. The involvement of lipid rafts in the regulation of integrin function. J Cell Sci 2002; 115 (5):963-972.
Kamata T, Tieu KK, Tarui T, Puzon-McLaughlin W, Hogg N, Takada Y. The role of the CPNKEKEC sequence in the beta(2) subunit I domain in regulation of integrin alpha(L)beta(2) (LFA-1). J Immunol 2002; 168 (5):2296-2301.
Robinson MJ, Tessier P, Poulsom R, Hogg N. The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells. J Biol Chem 2002; 277 (5):3658-3665.
Sebzda E, Bracke M, Tugal T, Hogg N, Cantrell DA. Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling. Nat Immunol 2002; 3 (3):251-258.
Other publications
Evans R, Patzak I, Svensson L, De Filippo K, Jones K, McDowall A, Hogg N. Integrins in immunity. J Cell Sci 2009; 122(Pt 2): 215-225.
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