Selected Publications
Labib K, Tercero JA and Diffley JFX. Uninterrupted MCM2-7 function required for DNA replication fork progression. Science 2000; 288: 1643-1647. PubMed
Tanaka S and Diffley JFX. Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation. Genes Dev 2002; 16: 2639-2649. PubMed Full text
Tercero JA and Diffley JFX. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature 2001; 412: 553-557. PubMed
Tercero JA, Longhese MP, Diffley JFX. A central role for DNA replication forks in checkpoint activation and response. Mol Cell 2003; 11: 1323-1336. PubMed
Mimura S, Seki T, Tanaka S, Diffley JFX. Phosphoylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control. Nature 2004; 431: 1118-1123. PubMed
Primary Research Publications
2009
Remus D;Diffley JFX. Eukaryotic DNA replication control: Lock and load, then fire. Curr Opin Cell Biol 2009; 21 (6):771-777. PubMed; DOI: 10.1016/j.ceb.2009.08.002.
Remus D;Beuron F;Tolun G;Griffith JD;Morris EP;Diffley JFX. Concerted Loading of Mcm2-7 Double Hexamers around DNA during DNA Replication Origin Licensing. Cell 2009; 139 (4):719-730. UKPubMed (open access); PubMed; DOI: 10.1016/j.cell.2009.10.015.
Omberg L;Meyerson JR;Kobayashi K;Drury LS;Diffley JFX;Alter O. Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression. Mol Syst Biol 2009; 5:312. UKPubMed (open access); PubMed; DOI: 10.1038/msb.2009.70.
Zegerman P;Diffley JFX. DNA replication as a target of the DNA damage checkpoint. DNA Repair (Amst) 2009; 8 (9 Spec Iss):1077-1088. PubMed; DOI: 10.1016/j.dnarep.2009.04.023.
Drury LS;Diffley JFX. Factors Affecting the Diversity of DNA Replication Licensing Control in Eukaryotes. Curr Biol 2009; 19 (6):530-535. PubMed; DOI: 10.1016/j.cub.2009.02.034.
2008
Segurado M;Diffley JFX. Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks. Genes Dev 2008; 22 (13):1816-1827. UKPubMed (open access); PubMed; DOI: 10.1101/gad.477208.
Zierhut C;Diffley JFX. Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. EMBO J 2008; 27 (13):1875-1885. UKPubMed (open access); PubMed; DOI: 10.1038/emboj.2008.111.
Baxter J;Diffley JFX. Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast. Mol Cell 2008; 30 (6):790-802. PubMed; DOI: 10.1016/j.molcel.2008.04.019.
2007
Zegerman P;Diffley JFX. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 2007; 445 (7125):281-285. DOI: 10.1038/nature05432.
2005
Mailand N;Diffley JFX. CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell 2005; 122 (6):915-926.
2004
Mimura S;Seki T;Tanaka S;Diffley JFX. Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control. Nature 2004; 431 (7012):1118-1123.
Diffley JFX. Regulation of early events in chromosome replication. Curr Biol 2004; 14 (18):R778-R786.
Wang XA;Ira G;Tercero JA;Holmes AM;Diffley JFX;Haber JE. Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiae. Mol Cell Biol 2004; 24 (16):6891-6899.
Merrick CJ;Jackson D;Diffley JFX. Visualization of altered replication dynamics after DNA damage in human cells. J Biol Chem 2004; 279 (19):20067-20075.
Early A;Drury LS;Diffley JFX. Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage. Philos Trans R Soc Lond B Biol Sci 2004; 359 (1441):31-38.
2003
Vernis L;Piskur J;Diffley JFX. Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae. Nucleic Acids Res 2003; 31 (19):e120. DOI: 10.1093/nar/gng121.
Zegerman P;Diffley JFX. Lessons in how to hold a fork. Nat Struct Biol 2003; 10 (10):778-779.
Tercero JA;Longhese MP;Diffley JFX. A central role for DNA replication forks in checkpoint activation and response. Mol Cell 2003; 11 (5):1323-1336.
2002
Tanaka S;Diffley JFX. Deregulated G(1)-cyclin expression induces genomic instability by preventing efficient pre-RC formation. Genes Dev 2002; 16 (20):2639-2649.
Tanaka S;Diffley JFX. Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nat Cell Biol 2002; 4 (3):198-207.
Diffley JFX;Labib K. The chromosome replication cycle. J Cell Sci 2002; 115 (5):869-872.
Other Publications
Zegerman P, Diffley JF DNA replication as a target of the DNA damage checkpoint. DNA Repair (Amst) 2009 Sep 2;8(9):1077-88
Diffley JFX. Regulation of early events in chromosome replication. Curr Biol 2004; 14(18):R778-R786
Vernis L, Piskur J, Diffley JFX. Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae. Nucleic Acids Res 2003; 31(19):e120
Zegerman P, Diffley JFX. Lessons in how to hold a fork. Nat Struct Biol 2003; 10(10):778-779
Diffley JFX, Labib K. The chromosome replication cycle. J Cell Sci 2002; 115(5):869-872
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