Mark Petronczki
Cell Division and Aneuploidy
See Mark Petronczki research profile
Several 3-year post-doctoral fellowships (yearly salary in the range of £25,500 - £33,000 plus location allowance of £2,370) are available in the Cell Division and Aneuploidy Laboratory led by Dr Mark Petronczki.
The group is using mammalian cells to study the final step of cell division: the separation of daughter cells during cytokinesis, which forms the basis for cell multiplication and plays a key role in preventing aneuploidy, a hallmark of cancer cells. The group's work focuses on two major questions:
- What are the molecular mechanisms orchestrating cytokinesis?
- What are the causes and consequences of cell division failure?
In particular, the group is interested in investigating the effects of tetraploidy on mitotic dynamics, genomic stability, and tumorigenesis.
For further details about these fellowships, please email mark.petronczki@cancer.org.uk
References
Petronczki M, et al. Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. Developmental Cell 2007; 12: 713-725.
Lénárt P, et al. The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Current Biology 2007; 17: 304-315.
Petronczki M, et al. Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1. Cell 2006; 126: 1049-1064.
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